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Thomas A. DeFalco

Tom is a molecular biologist interested in the mechanisms of plant-environment interactions and cell signaling. He studied plant molecular biology with a focus on calcium signaling at Queen's University (with Wayne Snedden) and received his PhD from University of Toronto (with Keiko Yoshioka). He then pursued postdoctoral work in the lab of Cyril Zipfel as an EMBO and NSERC fellow, where he worked on receptor kinases and the plant immune system. He is currently an Assistant Professor in the Department of Biology at Western where his lab uses a variety of biochemical, molecular, genetic, and systems approaches to tackle complex aspects of plant receptor signaling.

Background:
Assistant Professor, Western University, London, Canada (since 2022)
Postdoc, University of Zurich, Switzerland (2018-2022)
Postdoc, The Sainsbury Laboratory, Norwich, UK (2017-2018)
PhD, University of Toronto, Canada (2016)
MSc, Queen's University, Kingston, Canada (2010)


Teaching:
Bio 2601A - Organismal Physiology
Bio 3224G - Molecular Sensing and Signalling in Plants
Bio 4218F - Plant Pathology
Bio 9516A - Molecular Plant-Microbe Interactions

Current group members

Nathan Doner

Nathan is an NSERC postdoctoral fellow who joined in the lab in 2025, and is working on several projects related to downstream RK signaling.

Anka Colo

Anka is a graduate student who joined the lab in 2024, who is identifying novel kinase substrates downstream of RKs.

Colleen Barghout

Colleen is a graduate student who joined the lab in 2024, who is working to identify novel components of RK signaling pathways.

Maxwell Carito

Max a joined the lab as an undergraduate in 2024, and is now a graduate student working on the mechanisms of substrate targeting by protein kinases.

George Del Grosso

George is a graduate student working on mechanisms of pathway-specific RK signaling.

Laasya Patibandla

Laasya is an undergraduate researcher pursuing her 4th year thesis in the lab.

Derek Wang

Derek is an undergraduate research assistant who joined the lab in 2024.

Former members

Eleanor Khochaba (MSc, 2023-2025)

 

Erica Yip (NSERC USRA and thesis student, 2023-2024)

 

Lorenzo Ford (work-study undergrad, 2023-2024)

Gregory Wei (NSERC USRA summer student, 2023)

News

2025.09

Welcome back Max, who is starting his MSc in the lab!

 

2025.06

Latest preprint: "New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions"

https://doi.org/10.1101/2025.06.02.657414

 

2025.05

Welcome back George, who is starting his MSc with in the lab!

 

2025.01

Welcome Nathan, who is joining the lab as an NSERC postdoctoral fellow!

 

2025.01

Paper out at Plant Cell: "Arabidopsis WALL-ASSOCIATED KINASES are not required for oligogalacturonide-induced signaling and immunity"

https://doi.org/10.1093/plcell/koae317

See commentary here: https://doi.org/10.1093/plcell/koae318

© 2023 Thomas DeFalco

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